184例丛集性头痛患者临床特点分析

CLINICAL FEATURES OF CLUSTER HEADACHE：A CLINIC-BASED SURVEY FOR 184 PATIENTS

摘要:

目的:描述我国丛集性头痛(cluster headache,CH)患者临床特点。方法：收集2019年1月至2021年2月就诊于解放军总医院第一医学中心神经内科的CH患者相关临床信息并分析。 结果：在184例CH患者中,男：女=5.6:1,发作性CH占97.3%,慢性CH占2.7%。平均病程为11.4±7.9年,发病平均年龄为22.5±8.6岁,男性发病年龄大于女性(23.1±8.8岁vs. 19.3±6.0岁,P = 0.008)。有20.2%的患者同时患有其他类型的头痛。28.8%的患者有头痛家族史。最常见的疼痛部位是颞部(140例,76.1％)。单次头痛发作的持续时间中位数为90(60-120)分钟,有87.0%的患者头痛发作频率在2次/天及以下。每年丛集期发作频率少于1次者最多(50.0%),丛集期持续天数平均为37.6±28.9。 结论：女性患者比例较既往有所升高,女性比男性发病年龄早,部分患者有家族史。

Abstract:

Objective: To describe the clinical features of cluster headache (CH) in Chinese patients. Methods: Patients with CH admitted to the Department of Neurology of the First Medical Center of PLA General Hospital from January 2019 to February 2021 were enrolled, and clinical information were collected and analyzed. Results: In the 184 patients with CH, giving a male-to-female ratio of 5.6:1, 97.3% had episodic CH and 2.7% had chronic CH. The mean duration of disease was 11.4±7.9 years, and the mean age of onset was 22.5±8.5 years. The age of onset was older in males than in females (23.1±8.8 years vs. 19.3±6.0 years, P = 0.008). There were 20.2% patients suffered from other types of headache. And 28.8% patients had a positive family history of headache. The most common pain location was the temporal region (140 cases, 76.1%).The median duration of a single headache episode was 90 (60-120) minutes, and 87.0% of the patients had headache frequency of 2 times per day or less. The frequency of cluster period was less than one per year (50.0%), and the average duration of the cluster period was 37.6±28.9. Conclusion: The proportion of female patients is higher than before, the onset age of female patients is earlier than that of male patients, and some patients have family history.