Abstract:Abstract: Objective: To evaluate the efficacy and safety of CT-navigated percutaneous lumbar endoscopic discectomy(PELD) in the treatment of L5/S1 segment extreme lateral lumbar disc herniation(ELLDH). Methods:From September 2016 to February 2020,25 patients with extreme lateral lumbar disc herniation in the L5/S1 segment who underwent CT-navigated PELD were enrolled. Numeric rating scale(NRS) was applied to evaluate the pain score between pre- and post - operation,as well as,The Oswestry dysfunction index(ODI) was used to evaluate the functional recovery. The postoperative excellent and good rate was evaluated by the improved Macnab. Results: All 25 patients successfully completed this operation. The average operation time was (80.2 ± 20.6) min, and the average hospital stay was (7.3 ± 4.5) days. The results of the NRS score showed that the postoperative pain score was significantly decreased compared with that before the operation. ODI results showed that the patient's ODI gradually decreased after the operation, and the function gradually recovered. The MacNab excellent and good rate is 96% (24/25) by the time of 12 months after surgery. During the follow-up period, 2 patients (8%) experienced recurrent and accepted secondary PELD. Conclusion: CT-navigated PELD provides the optimal surgical path , it’s a safely and effectively surgery for L5/S1 ELLDH.