AMPK在神经病理性疼痛中的作用机制及相关研究进展

Mechanisms and research progress of AMPK in neuropathic pain

摘要:

神经病理性疼痛（Neuropathic pain, NP）由躯体感觉神经系统的损伤或疾病引起，其发生机制尚不完全明确，对传统的镇痛药物反应不佳，极难治疗，严重影响患者正常的工作和生活，是临床和公共卫生的重要难题。越来越多的研究表明，腺苷酸激活蛋白激酶 (AMP-activated protein kinase, AMPK) 在神经性病理疼痛的发生、发展和维持过程起到关键的调控作用，未来有望成为疼痛治疗的新靶标。本综述回顾和展示了AMPK在治疗神经病理性疼痛中的作用及作用机制，及AMPK为靶点的化合物在疼痛治疗中的应用，为预防和治疗神经病理性疼痛提供新的思路和方法。

Abstract:

Neuropathic pain (NP) is caused by damage or disease of the somatosensory nervous system, but the underlying mechanism is unclear. NP profoundly impairs the patient’s quality of life, the clinical management of NP is di?cult as current pain drugs are marginally e?ective and display unacceptable side e?ects. More and more studies have shown that AMPK plays a key role in regulating neuropathic pain, and is a promising drug target. This review demonstrates the role and the mechanisms of AMPK in the treatment of neuropathic pain, and the application and research progress of compounds targeting AMPK in pain treatment, which may provide new ideas and methods for the prevention and treatment of NP.