急慢性疼痛的脑磁共振动态功能连接分析研究进展*

Progress of MRI based dynamic functional connectivity analysis on pain

摘要:

疼痛作为一种令人不悦的主观感受，不仅与注意力、情绪、运动等紧密相关，并且具有动态特性。这种复杂且动态的交互关系可能反映了疼痛处理的神经编码机制。借助以功能磁共振成像为代表的无创神经影像学方法，已发现脑网络的异常激活参与疼痛产生。动态功能连接(dynamic functional connectivity，dFC)作为一种新的分析方法，能够观察脑区功能连接的时变过程，帮助探索疼痛连接组脑网络的动态交流与重构。本文概述了急、慢性疼痛研究中常用的dFC分析方法，并对其在在相关研究中的应用进行综述，为进一步理解疼痛处理与调节的中枢机制提供新思路。

Abstract:

As an unpleasant subjective experience, pain shows not only closely interaction with attention, emotion, behavior, etc., but also constant fluctuation. The complex and dynamic interaction between pain and cognition may help to reveal the neural coding mechanism of pain processing. With the help of noninvasive neuroimaging methods such as functional magnetic resonance imaging (fMRI), abnormal activation of brain networks has been found to be involved in the pain processing. As a new analytical method, dynamic functional connectivity (dFC) makes it possible to observe the time-varying process of functional connectivity between brain regions, helping to explore the dynamic communication and reorganization of “pain connectome”. This paper summarize dFC methods commonly used in acute or chronic pain research, and their application, so as to provide insights for better understanding mechanism of pain processing and modulation.