维生素D与慢性疼痛的临床研究进展

Clinical research progress of vitamin D and chronic pain

摘要:

维生素D是一种脂溶类维生素，也被认为是一种激素。不少研究表明维生素D与急慢性疼痛相关，维生素D和疼痛存在很多潜在生理机制。大部分随机对照试验显示维生素D补充剂对疼痛管理有积极作用，这可能与患者25-（OH）D3基线水平有关。迄今为止，维生素D补充剂没有出现不良反应，而且也易于管理。本文通过学习维生素D和头痛、肌肉骨骼疼痛、神经病理性疼痛的相关研究，研究维生素D和疼痛方面的证据，阐明当前的知识是否支持25-（OH）D3水平缺乏的疼痛患者补充维生素D，为临床疼痛管理提供新思路。

Abstract:

Vitamin D is a fat soluble vitamin, also known as a hormone. Many studies have shown that vitamin D is related to acute and chronic pain, but the causal relationship is not obvious, and the physiological mechanism of vitamin D and pain is not completely clear. Most randomized controlled trials have shown that vitamin D supplements have a positive effect on pain management, which may be related to the baseline level of 25 - (OH) D3. So far, vitamin D supplements have not had adverse reactions and are easy to manage. In this paper, we reviewed the correlation and potential mechanisms of vitamin D and headache, musculoskeletal pain and neuropathic pain, study the evidence of vitamin D and pain, and clarify whether current knowledge supports vitamin D supplementation in patients with 25 - (OH) D3 deficiency and pain, so as to provide new ideas for clinical pain management.