TRPV1通道在病理性疼痛中的研究进展*

Research Progress of TRPV1 Channel in Pathological Pain*

摘要:

疼痛是机体对伤害性刺激的一种特异性反应。其主要分为伤害性疼痛和病理性疼痛,后者主要包括炎症性疼痛、神经病理性疼痛和癌性疼痛^[1]。瞬时受体电位香草酸亚型 1(transient receptor potential vanilloid subfamily 1, TRPV1)通道已经被证明在病理性疼痛中起重要作用。本文就TRPV1通道在病理性疼痛中的作用做一综述,希望能为病理性疼痛的治疗提供新的思路。

Abstract:

Pain is a specific response of the body to noxious stimuli. It is mainly divided into nociceptive pain and pathological pain, the latter mainly including inflammatory pain, neuropathic pain and cancer pain.The transient receptor potential vanilloid subfamily 1(TPRV1)channel has been shown to play an important role in pathological pain. This paper reviews the role of TRPV1 channel in pathological pain, hoping to provide new ideas for the treatment of pathological pain.