Abstract:sympathetic modulation has been widely used in the treatment of a variety of related diseases, such as hyperhidrosis, Raynaud"s disease, complex regional pain syndrome, arteriosclerotic occlusive disease of lower extremities and so on. It is mainly divided into three categories, the first is oral drug therapy, and the second is sympathetic non-destructive block, such as stellate ganglion block, then the third is sympathetic destructive block. However, with the rapid development of imaging technology, it has developed from traditional endoscopic destructive block to CT-guided minimally invasive destructive block, which not only reduces the risks and complications related to surgery, but also improves the satisfaction of patients. This article reviews the clinical application of sympathetic modulation.