细胞疗法治疗椎间盘退变研究进展*

Research progress of cell therapy for intervertebral disc degeneration

摘要:

椎间盘退变可导致慢性腰痛和感觉运动障碍等症状,其发病率随人类寿命的延长而不断上升,给社会造成了巨大的经济负担。目前的治疗手段包括保守治疗和手术治疗,但只能减轻或消除症状,不能恢复椎间盘的正常组织结构和固有功能,且存在较多并发症。针对退变椎间盘中细胞数量减少、功能减退这一现象,向椎间盘内补充细胞的细胞疗法可增加髓核中蛋白多糖和胶原的含量,恢复椎间盘正常的组织结构和生物力学功能,有望实现椎间盘再生。本文就目前细胞疗法治疗椎间盘退变的研究进展作一综述。

Abstract:

Intervertebral disc degeneration can cause chronic back pain ,sensory disturbance and dyskinesia. The incidence of human intervertebral disc degeneration has been increasing with the prolongation of human life span, which has caused enormous financial burden to society. The current treatment methods include conservative treatment and surgical treatment, but they can only reduce or eliminate symptoms, instead of restoring the normal tissue structure and intrinsic function of the disc, and there are many complications. Since the quantity of cells in degenerative disc decreases and the function declines, cell therapy which means delivering cells to the disc can increase the content of proteoglycan and collagen in the nucleus pulposus, restore the normal tissue structure and biomechanical function of the disc, and it is expected to realize the regeneration of the disc. This article reviews the current research progress of cell therapy.