超声引导颈神经根射频治疗上肢带状疱疹神经痛的临床研究
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中日友好医院

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Radiofrequency treatment of herpes zoster neuralgia in the upper extremities by ultrasound-guided
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China-Japan Friendship Hospital

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    摘要:

    目的 探索超声引导下颈神经根脉冲射频术治疗上肢带状疱疹神经痛的近远期疗效,并与C型臂透视手术方式进行比较。方法 采用前瞻性随机对照的研究方法,选择中日友好医院全国疼痛诊疗研究中心符合入组条件的73例上肢带状疱疹神经痛患者,病程时间1-3个月,分为超声组(n=36)和透视组(n=37)。射频针穿刺至病变颈神经根确认位置后,每个靶点脉冲射频治疗42℃,360s。主要终点指标:术后1天、2周、4周、12周和24周疼痛NRS评分。次要终点指标:镇痛药物和钙通道拮抗剂使用情况。结果 超声组和透视组术后1天NRS疼痛评分降低至4.0和5.4,P<0.01;术后2周疼痛评分降低至3.4和4.6,P<0.05;术后4周疼痛评分降低至3.0和3.9,P<0.05。术后第1天超声组和透视组分别有8例和3例停用镇痛药,P<0.05。超声组平均手术时间30min,明显低于透视组(P<0.01)。结论 超声引导下颈神经根脉冲射频能够有效治疗上肢带状疱疹神经痛,短期镇痛效果优于透视组,长期疗效相近,手术时间明显缩短。

    Abstract:

    Objective To explore the short-term and long-term effects of ultrasound-guided cervical nerve root pulse radiofrequency surgery in the treatment of herpes zoster neuralgia in the upper extremity, and to compare it with C-arm fluoroscopy guided surgery. Methods A prospective, randomized, controlled study was conducted in 73 patients with neuralgia due to herpes zoster of the upper extremity who were admitted to the National Pain Management and Research Center, China-Japan Friendship Hospital. They were divided into ultrasound guidance group (n=36) and fluoroscopic guidance group (n=37). The target nerve roots accepted pulse radiofrequency therapy at 42 °C, 360s. . Main outcome measures: NRS at 1 day, 2, 4, 12 and 24 weeks after operation were recorded. The secondary end points were the use of analgesics and calcium channel antagonists. Results The NRS pain score decreased to 4.0 and 5.4 in ultrasound group and fluoroscopy group, P < 0.01; 3.4 and 4.6 in 2 weeks, P < 0.05; 3.0 and 3.9 in 4 weeks, P < 0.05. On the first day after operation, 8 cases in ultrasound group and 3 cases in fluoroscopy group stopped using analgesics (P < 0.05). The average operation time of ultrasound group was 30 minutes, significantly lower than that of fluoroscopy group (P < 0.01) .Conclusion The short-term analgesic effect of ultrasound group was better than that of fluoroscopy group, the long-term effect was similar, and the operation time was significantly shorten.

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  • 收稿日期:2020-06-11
  • 最后修改日期:2020-07-30
  • 录用日期:2020-12-09
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