JAK/STAT信号通路在骨关节炎中的研究进展

Research Advances of JAK/STAT Signaling Pathway in osteoarthritis

摘要:

骨关节炎 (osteoarthritis, OA) 是一种退行性慢性关节疾病,目前临床治疗效果不佳,严重影响患者的生活质量。JAK/STAT信号通路不仅参与调节正常的生理过程, 在骨关节炎的发生发展中也扮演关键角色,尤其是在炎症及软骨及骨破坏方面意义重大。本文就近年来JAK/STAT信号通路参与骨关节炎发生发展、骨关节炎炎症、骨关节炎软骨及软骨下骨退变机制以及与该通路相关的靶点在骨关节炎治疗中的研究现状进行综述。

Abstract:

Osteoarthritis (OA)) is a degenerative chronic joint disease. At present, the clinical treatment effect is not good, which seriously affects the quality of life of patients. JAK/STAT signaling pathway not only participates in the regulation of normal physiological processes, but also plays a key role in the occurrence and development of osteoarthritis, especially in inflammation and cartilage and bone destruction. This article reviews the role of JAK/STAT signaling pathway in the occurrence and development of osteoarthritis, inflammation of osteoarthritis, the mechanism of osteoarthritis cartilage and subchondral bone degeneration, and the research status of targets related to this pathway in the treatment of osteoarthritis.