基于功能性近红外光谱技术疼痛研究的任务设计方法述评
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1.成都中医药大学;2.山西中医药大学

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国家科技支撑计划(2013BAI05B00),国家自然科学基金(81673887)


A review of the task design method for pain research based on fNIRS
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Chengdu University of TCM

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    摘要:

    随着神经影像学的发展,医学影像技术被广泛应用于临床研究。其中,功能性近红外光谱(functional near-infrared spectroscopy,fNIRS)作为新兴技术,是一种非侵入性、非电离的脑血流动力学功能成像方法,可以用于研究人类健康及病理状态下的脑功能。疼痛作为第五大生命体征,其中枢机制仍旧是研究热点,是fNIRS研究的良好载体。根据是否要求受试者在数据采集期间执行相应的任务,fNIRS分为静息态和任务态,与静息态相比,任务态运用较广、更具时效性,且设计方案多样化,包括电刺激、温度刺激等单一任务及机械刺激与认知结合的多任务设计。基于fNIRS研究的不断深入,本文从任务态的设计切入,以单一任务和多任务设计为着眼点,对近年来疼痛相关的fNIRS研究的文献进行评述,以期为今后的研究提供参考。

    Abstract:

    With the development of neuroimaging, medical imaging technology has been widely used in clinical research. Among them, functional near-infrared spectroscopy (fNIRS), as an emerging technology, is a non-invasive and non-ionizing method for monitoring and imaging cerebral hemodynamics, which can be used to study brain function in human health and pathology. Pain is the fifth vital sign of human, and its central mechanism is still a research hotspot, which is a good carrier for fNIRS research. According to whether the subjects are required to perform corresponding tasks during data collection, fNIRS is divided into resting state and task state. Compared with resting state, task state is more widely used, more time-sensitive, and the design options are diverse, including Single task such as electrical stimulation and temperature stimulation, and multi-task design combining mechanical stimulation and cognition. Based on the continuous deepening of fNIRS research, this article starts with the design of the task state, focusing on the single-task and multi-task design, reviews the recent literature on pain-related fNIRS research, in order to provide a reference for future research.

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  • 收稿日期:2020-03-30
  • 最后修改日期:2020-06-15
  • 录用日期:2020-07-16
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