终末期恶性肿瘤患者临终前使用吗啡注射液44例回顾性分析

A retrospective analysis of 44 cases of terminal malignant tumor treated with morphine injection before death

摘要:

目的 观察盐酸吗啡注射液治疗终末期肿瘤患者疼痛及呼吸困难的疗效和安全性。方法 收集2017年1月至2019年12月使用盐酸吗啡注射液治疗疼痛及呼吸困难的临终前肿瘤患者44例,观察治疗前后患者疼痛及呼吸困难症状变化,分析治疗后的疗效和不良反应。结果 36例疼痛患者治疗前疼痛评分8.37±1.55,注射盐酸吗啡30分钟后疼痛评分3.96±1.30,60分钟后疼痛评分1.93±0.88(P值﹤0.05)。26例呼吸困难患者注射盐酸吗啡后症状均有缓解,治疗后呼吸频率下降,血氧饱和度与注射盐酸吗啡前无明显变化(P值>0.05)。主要副作用为嗜睡(63.6%),未出现呼吸抑制。结论 盐酸吗啡注射液用于治疗终末期肿瘤患者疼痛及呼吸困难安全有效。

Abstract:

Objective To observe the efficacy and safety of morphine hydrochloride injection in the treatment of pain and dyspnea in patients with end-stage tumor. Methods From January 2017 to December 2019, 44 cases of terminal tumor patients with pain and dyspnea were treated with morphine hydrochloride injection. The changes of symptoms of pain and dyspnea were observed before and after treatment, and the curative effect and adverse reactions were analyzed. Results 36 patients had pain score of 8.37±1.55 before treatment, 3.96±1.30 after 30 minutes of morphine hydrochloride injection, and 1.93±0.88 after 60 minutes (P<0.05). The symptoms of 26 patients with dyspnea were relieved after injection of morphine hydrochloride. After treatment, the respiratory rate decreased, and there was no significant change in blood oxygen saturation (P>0.05). The main side effect was lethargy (63.6%), without respiratory depression. Conclusion Morphine Hydrochloride Injection is safe and effective in the treatment of pain and dyspnoea in patients with end-stage tumor.