Th17细胞及相关细胞因子在神经病理性疼痛中的研究进展

Rearseach progress on Th17 cells and related cytokines in neuropathic pain

摘要:

神经病理性疼痛是作为威胁人类健康的重要问题之一，机制目前尚未完全阐明，目前治疗神经病理性疼痛的药物效果欠佳，同时伴有不同程度的副作用[4],因此迫切需要寻找新的治疗策略。最近研究表明免疫细胞通过释放细胞因子以及趋化因子等产，参与神经病理性疼痛的发生和发展。Th17细胞是最近发现的CD4+T淋巴辅助细胞，主要通过分泌细胞因子在神经病理性疼痛中发挥作用。本文就Th17细胞及相关细胞因子在神经病理性疼痛中的研究进展作一综述，为神经病理性疼痛的治疗提供新的治疗靶点。

Abstract:

Abstract: Neuropathic pain is one of the important problems threatening human health,At present,the pathogenesis of neuropathic pain is still nuclear. drugs for the treatment of neuropathic pain are not fully effective and different degrees of side effects, it is urgent to find new treatment method.Recent studies have shown that immune cells are involved in the occurrence and development of neuropathic pain by releasing cytokines and chemokines.Th17 cells are the recently discovered CD4+T lymphocyte helper cells, which play a role in neuropathic pain with secreting cytokines.This article reviews the research progress of Th17 cells and related cytokines in neuropathic pain for providing a new therapeutic target for neuropathic pain.