Objective: To compare and analyze the effect of intraplate radiofrequency combined with low-dose collagenase lysis and simple intraplate collagenase on the height of cervical intervertebral space. Methods: The clinical data of 45 patients with cervical disc herniation treated with radiofrequency combined with low-dose collagenase lysis and 46 patients with cervical disc herniation were retrospectively analyzed. The height of the lesion intervertebral space changes of the preoperative and postoperative 3 months were compared between the two groups. Results: Compared with preoperative, the heights of the leading edge, posterior margin and midpoint of the intervertebral space of the two groups were decreased at 3 months after operation (P<0.01). The intradural radiofrequency combined with small dose was compared between the two groups. The reduction of the leading edge, the trailing edge and the midpoint of the intervertebral space in the collagenase-dissolving group was smaller than that in the intra-dissection collagenase-dissolving group, and there was a statistical difference (P<0.01). Conclusion: Intradural radiofrequency combined with low-dose collagenase and simple intraplate collagenase can cause postoperative cervical intervertebral space height drop, but the intracavitary radiofrequency combined with low-dose collagenase dissolution has less cervical intervertebral space height.