持续性躯体形式疼痛障碍患者血清激素水平的研究分析 *

ANALYSIS OF SERUM HORMONE LEVELS IN PATIENTS WITH PERSISTENT SOMATOFORM PAIN DISORDER

摘要:

目的：分析持续性躯体形式疼痛障碍患者(Persistent somatoform pain disorder, PSPD)的血清激素水平,探讨血清激素对PSPD疾病发生发展的影响。方法：选取我院收治的16例PSPD患者与16例年龄、性别和教育程度相匹配的健康人员作为对照组,获取PSPD患者和对照组人员的血清激素指标。使用视觉模拟量表(Visual Analogue Scale, VAS)评估PSPD患者的疼痛程度,并采用焦虑自评量表(Self-Rating Anxiety Scale, SAS)和抑郁自评量表(Self-Rating Depression Scale, SDS)评估PSPD患者和健康对照组人员的心理健康状况。结果：与对照组相比,PSPD患者SAS和SDS评分显著增高(P < 0.001)。16例PSPD患者均出现多种激素异常(定义为血清激素水平高于或低于正常范围),大部分激素水平异常显示高于正常人的水平,只有少数几种激素水平异常显示低于正常人水准。将选取的16例PSPD患者与健康对照组的激素水平进行分析比较,我们发现PSPD患者的皮质醇、醛固酮和催乳素水平显著高于正常人(P < 0.05)。结论：PSPD患者的血清激素异常升高,提示血清激素水平可能是PSPD的潜在生物标志物,为PSPD患者的临床诊断和治疗提供理论依据。

Abstract:

Objective: To analyze the serum hormone levels of patients with persistent somatoform pain disorder (PSPD) and to explore the effect of serum hormones on the development of PSPD disease. Methods: Sixteen patients with PSPD admitted to our hospital and 16 healthy persons with age, gender and education level were selected as the control group. The corresponding serum hormones were obtained from PSPD patients and control subjects. The degree of pain in patients with PSPD was assessed using a Visual Analogue Scale (VAS). The Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) were used to evaluate the anxiety and depression of PSPD patients and healthy controls. Results: SAS and SDS scores were significantly higher in PSPD patients compared with healthy controls (P < 0.001). A variety of hormonal abnormalities occurred in 16 patients with PSPD (abnormality defined as a serum concentration or level above or below the normal range). In patients with hormonal abnormalities, most of the hormone levels showed higher levels than normal, and only a few hormone levels were abnormally lower than normal. Comparing the hormone levels of 16 patients with PSPD and healthy controls, we found that the levels of cortisol, aldosterone and prolactin in PSPD patients were significantly higher than those in normal controls (P < 0.05). Conclusion: Serum hormones in patients with PSPD are abnormally elevated, suggesting that serum hormone levels may be potential biomarkers of PSPD, providing a theoretical basis for clinical diagnosis and treatment of patients with PSPD.