利多卡因凝胶贴膏联合加巴喷丁治疗带状疱疹后神经痛的疗效观察

Therapeutic effect of lidocaine gel paste combined with gabapentin on postherpetic neuralgia

摘要:

目的 观察利多卡因凝胶贴膏联合加巴喷丁治疗带状疱疹后神经痛的疗效。方法 选择80例确诊为带状疱疹后神经痛且有爆发痛的患者为研究对象,根据治疗方法的不同,采用数字表法随机分为对照组(C组)和试验组(T组),每组40例。C组采用加巴喷丁治疗，T组采用加巴喷丁联合利多卡因凝胶贴膏治疗。观察2组患者治疗前、治疗后7天﹑14天﹑21天、30天﹑60天的视觉模拟评分（VAS）、睡眠质量评分、加巴喷丁使用量、患者总体满意度及不良反应发生情况。结果 T组治疗后7天﹑14天﹑21天、30天﹑60天VAS评分低于C组（P<0.05），T组治疗后7天﹑14天﹑21天、30天﹑60天睡眠质量评分明显优于C组（P<0.05），T组加巴喷丁使用量明显低于C组（P<0.05）。两组患者治疗期间均未见明显不良反应发生。T组患者总体满意率高于C组患者。结论 利多卡因凝胶贴膏联合加巴喷丁治疗带状疱疹后神经痛疗效确切，能减轻患者疼痛感，且不会增加不良反应，治疗安全有效。

Abstract:

Abstract Objective To observe the efficacy of Lidocaine gel paste combined with gabapentin in the treatment of postherpetic neuralgia.Methods Eighty patients with post-herpetic neuralgia and outbreak pain were selected as subjects. According to different treatment methods, the digital table method was randomly divided into the control group (group C) and the test group (group T) ，with 40 cases in each group.Group C was treated with gabapentin, and group T was treated with gabapentin plus Lidocaine gel paste.The Visual analogue scale (VAS), sleep quality score,gabapentin usage,overall patient satisfaction and adverse reactions of the two groups were observed before treatment, after 7 days, after 14 days, after 21 days, after 30 days, and after 60 days.Results The VAS scores of group T were lower than that of group C at 7 days, 14 days, 21 days, 30 days and 60 days after treatment(P<0.05) . The quality of sleep in group T was significantly better than that of group C at 7 days, 14 days, 21 days, 30 days and 60 days after treatment(P<0.05). The amount of gabapentin in group T was significantly lower than that in group C (P<0.05).No significant adverse reactions occurred during the treatment of both groups. The overall satisfaction rate of patients in group T was higher than that in group C.Conclusion Lidocaine gel paste combined with gabapentin is effective in the treatment of post-herpetic neuralgia, which can reduce the pain of patients, and will not increase the adverse reactions, and the treatment is safe and effective.