炎性小体在神经性疼痛中的研究进展

Advances in research on the role and mechanism of Inflammasome in neuropathic pain

摘要:

神经性疼痛是指由影响躯体感觉系统的病变或疾病引起的疼痛,是最难治疗的神经系统疾病之一,同时也是全世界主要的公共卫生问题。近年来的研究表明,炎性小体作为一种先天免疫复合物,通过开启炎症反应过程参与神经性疼痛的发生及发展过程。本文通过查阅经典以及最新的相关文献,总结了炎症小体结构特点及在多种神经性疼痛相关疾病中的作用和相关机制,以及靶向炎症小体活性在神经性疼痛中的治疗,为神经性疼痛的发生机制及治疗前景提供新的思路。

Abstract:

Neuropathic pain is caused by a disease or disease affecting the somatosensory system. It is one of the most difficult neurological diseases to treat, and it is also a major public health problem worldwide. Recent studies have shown that Inflammasome, as an innate immune complex, participate in the development and progression of neuropathic pain by opening the inflammatory process. This article summarizes the structural features of Inflammasome and its role in a variety of neuropathic pain-related diseases and related mechanisms, as well as the treatment of targeting Inflammasome activity in neuropathic pain, by reviewing the classic and the latest relevant literature. New ideas for the mechanism and treatment of sexual pain.