Abstract:【Abstract】Objective: Retrospective analysis the clinical effect of CT guided second-generation low temperature plasma medullary nucleus ablation combined with intervertebral disc ozone injection in the treatment of lumbar intervertebral disc herniation. Methods: Enroll 48 cases of lumbar intervertebral disc herniation treated by CT guided second generation low temperature plasma medullary nucleus ablation combined with intervertebral disc ozone injection. Compare the VAS scores before, 1 week and 3 months after the surgery,evaluate the treatment results of 3 months after operation by MacNab efficacy evaluation criteria. Results: The VAS scores of 48 patients in 1 week and 3 months after operation were lower than those before operation, and the difference was statistically significant (P<0.01). The excellent rate of curative effect in 3 months after operation was 77.08% (37/48 cases), and the effective rate was 91.67% (44/48 cases). No complications such as nerve damage were found in all cases. Conclusion: Under CT guidance, the second generation of low temperature plasma medullary nucleus ablation combined with ozone disc injection in the treatment of lumbar intervertebral disc herniation has the advantages of small trauma and good curative effect. It is an effective minimally invasive surgical method for the treatment of lumbar intervertebral disc herniation.