脂质调节TRPs通道活性介导疼痛的作用机制

Mechanism of Pain Mediated by“Lipid-TRPs Ion Channel”

摘要:

疼痛是多种临床疾病的主要表现和亟待解决的难题。瞬时电位受体离子通道 (transient receptor potential, TRPs）家族因其参与疼痛和痛觉敏化的信号传导，备受关注。TRPs通道对脂质环境高度敏感，多种脂质或类脂本身就是TRPs通道的激动剂。迄今为止，已发现50多种内源性脂类物质可以调节感觉神经元中的TRPs通道活性，主要包括环氧化酶代谢物、脂氧合酶代谢物、细胞色素-P450途径代谢物、磷脂和溶血磷脂代谢物。因此，TRPs可以整合并传导多种脂质代谢途径的异常信号进而介导疼痛，针对脂质代谢紊乱的镇痛治疗措施极具潜力。本文重点阐释了脂质调节TRPs通道活性介导疼痛的作用机制，以期为临床缓解疼痛提供新的思路。

Abstract:

Pain is the main manifestation of many clinical diseases and a difficult problem to be solved. The transient receptor potential family (TRPs) has attracted much attention because of its involvement in pain and pain sensitization signal transduction. TRPs are highly sensitive to lipid environments, and a variety of lipoids or lipids are agonists of TRPs. So far, more than 50 kinds of endogenous lipids have been found to regulate the activity of TRPs channels in sensory neurons, including metabolites of the cyclooxygenase, lipoxygenase and cytochrome-P450 pathways, phospholipids and lysophospholipids. Therefore, TRPs can integrate and transmit abnormal signals of various lipid metabolism pathways and then mediate pain, and the analgesic treatment measures for lipid metabolism disorder have great potential. This paper focuses on the mechanism of lipids regulating TRPs channel to mediate pain in order to provide a new idea for clinical pain relief.