带状疱疹后神经痛发病危险因素研究进展

Advance in research on postherpetic neuralgia and its risk factors

摘要:

带状疱疹后神经痛（postherpetic neuralgia, PHN）是带状疱疹（Herpes Zoster, HZ）最常发生且难以控制的并发症，长期的疼痛不仅会影响患者的睡眠及生活质量，还会导致焦虑、抑郁，甚至自杀。目前PHN治疗主要以止痛为主，但效果不显著。随着研究的不断深入，PHN发病危险因素日益受到重视。较为公认的高危因素是年龄，临床上还发现带状疱疹急性期的疼痛程度和皮损程度也是重要危险因素。此外还有尚未明确定论，需要继续研究的影响因素，如免疫功能状态、炎症因子改变等。为早期预防及早期干预PHN提供理论依据。本文就国内外对带状疱疹后神经痛发病危险因素的相关研究进行概述。

Abstract:

Postherpetic neuralgia(PHN) is the most common complication of herpes zoster and the most difficult to control.Chronic pain not only affects the quality of sleep and life,but also leads to anxiety and depression,even suicide. At present,analgesic is the mainly treatment of PHN,but the effect is not significant. With the deepening of research,the risk factors of PHN are increasingly valued. Age is currently recognized as a high risk factor,the degree of pain and skin lesions in the acute phase of herpes zoster are also important in clinical. In addition,there are still undetermined factors that need to be further studies,such as the state of immune function and the change of inflammatory factors. Those provide theoretical basis for early prevention and intervention of PHN. In this paper, the domestic and international studies of the risk factors of PHN were summarized.