STin2 VNTR基因多态性与偏头痛易感性的Meta分析

Association between STin2 VNTR and Migraine: a meta-analysisGuan Xin-ying1, Dong Xin2, Wan Qi2△

摘要:

目的 探讨五羟色胺转运蛋白(5-HTT)STin VNTR多态性与偏头痛易感性之间的关系。 方法 通过检索PubMed和EMBASE数据库收集已发表的有关5-HTT STinVNTR多态性与偏头痛易感性关系的病例对照研究,采用固定效应模型或随机效应模型合并效应量ORs和95%CIs以评价5-HTT STinVNTR多态性与偏头痛易感性的关联性。 结果 meta分析提示STin2.12/12基因型与无先兆偏头痛易感性呈正相关(OR = 1.31, 95%CI = 1.03-1.66, P = 0.03; I² = 31%)。 结论 此项研究表明5-HTT STin2.12/12可能是无先兆偏头痛易感的危险因素。

Abstract:

Objective To investigate the association between the 5-HTT STin variable-number tandem repeat (VNTR) polymorphisms and migraine. Methods Relevant studies were identified using the PubMed and EMBASE databases. We used odds ratios (ORs) with 95% confidence intervals (CIs) to evaluate the effect of 5-HTT STin VNTR polymorphisms on migraine in a random-effects or fixed-effects model. We also performed subgroup analyses by ethnicity and migraine status. Results The overall results indicated that the STin2.12/12 genotype significantly increased the risk of the development of MO (OR = 1.31, 95%CI = 1.03-1.66, P = 0.03; I² = 31%). Conclusion Thus, this meta-analysis demonstrates that the 5-HTT STin2.12/12 genotype may serve as a risk factor for MO.