Abstract:Objective: to observe the therapeutic effect of radiofrequency thermocoagulation of saphenous nerve under B-ultrasound guidance in the treatment of intractable medial knee pain. Methods: sixty cases of knee osteoarthritis with anterior and medial knee pain were randomly divided into two groups: Observation group(group O) and Control group (group C). group O received radiofrequency thermocoagulation of saphenous nerve guided by B-ultrasound. group C received nerve block of perigenu neuralgia. Both groups received intra articular injection of sodium hyaluronate. Osteoarthritis index (western ontario and mcMaster universities osteoarthritis index, WOMAC) ,and visual analogue score ( VAS) were recorded before treatment, and 1 week, 6 weeks, 3 months and 6 months after treatment to evaluate the therapeutic effect and adverse effects. Results:The WOMAC and VAS were decreased in both groups at 1 week after treatment. Compared with the group C, knee pain decreased more significantly in group R at 1 week after treatment, The WOMAC and VAS in group O were significantly lower than those in group C after 6 weeks. No serious adverse effect appeared in this study. Conclusion: Radiofrequency the rmocoagulation of saphenous nerve guided by B-ultrasound is accurate and can effectively relieve anterior and medial pain in knee osteoarthritis, It may be a new method for the treatment of knee osteoarthritis.