非甾体类抗炎药物在癌痛治疗中的进展

RECENT ADVANCES OF NSAIDS IN CANCER PAIN MANAGEMENT

摘要:

非甾体类抗炎药物（Non-Steroidal Anti-inflammatory Drugs，NSAIDs）作为基础药物，被广泛应用于癌痛治疗领域。随着治疗经验的逐步累积，临床针对传统“三阶梯镇痛原则”产生了不同看法：有研究认为针对中度癌痛治疗，单独使用NSAIDs或强阿片类药物降级使用的治疗效果可能不劣于NSAIDs与弱阿片联用；同时，NSAIDs作为核心药物与强阿片类药物联用针对重度癌痛患者的中长期使用风险及收益有待商榷。近年来，新型NSAIDs的面世也为癌痛治疗提供了更新更多样的治疗手段，在使用相关药品时应警惕药品不良反应，关注合理配伍及个体化用药。

Abstract:

Non-Steroidal Anti-inflammatory Drugs, as the most basic agents, are widely used in cancer pain treatment. With the accumulation of experience in medication therapy, the common sense about “Three ladders pain analgesic” needs to be re-evaluated. New evidence indicates NSAIDs alone may not be inferior to the “NSAIDs-weak opioids” combination in moderate cancer pain. Meanwhile, risks/benefits are open to questions for the long-term use of “NSAIDs-opioids” combination. Individualized medication and drug compatibility issues still remain to be focused for better rational use of drugs.