调节阿片受体MOR胞内信号转导的分子机制研究进展

Research progress in the intracellular molecular signal transduction mechanisms of opioid receptor MOR

摘要:

阿片受体MOR主要负责阿片类药物的镇痛作用，其胞内信号转导机制已能够被系统地阐述。本综述通过系统地整理近几年来的文献，比较详细地介绍了阿片受体MOR产生镇痛作用的完整信号转导过程及调节其信号转导的多种蛋白质。本综述总结了已知影响阿片受体MOR功能发挥的MOR基因OPRM1剪接异构体、离子通道、外周性阿片肽和晶体结构的最新知识，以探讨阿片类药物在疼痛治疗中的应用和临床价值。

Abstract:

The μ opioid receptor MOR is mainly responsible for the analgesic effect of opioids, and its signal transduction mechanism has been systematically elucidated. This review systematically organizes the documents in recent years, and introduces the complete signal transduction process of μ opioid receptor MOR production and various proteins that regulate its signal transduction. The latest known knowledge about the μ opioid receptor gene OPRM1 splice variants, ion channels, peripheral opioid peptide and crystal structure affecting function of μ opioid receptor MOR is summarized to explore the application and clinical value of opioids in the treatment of pain in this review.