普瑞巴林联合硫酸软骨素对膝骨关节炎疼痛患者MMP-3及TIMP-1因子水平的影响

Effects of pregabalin combined with chondroitin sulfate on MMP-3 and TIMP-1 levels in patients with knee osteoarthritis pain

摘要:

目的：探究普瑞巴林联合硫酸软骨素对膝骨关节炎疼痛患者间充质溶解素（MMP-3）及蛋白酶抑制剂1（TIMP-）1因子水平的影响。方法：在院内收治的膝骨关节炎疼痛患者中选取100例进行分组调查，依据所采用治疗方案的不同，将单纯硫酸软骨素治疗50例作为对照组，将普瑞巴林联合硫酸软骨素治疗50例作为观察组，观察两组患者治疗效果。结果：治疗后，观察组患者MMP-3水平明显低于对照组，TIMP-1水平明显高于对照组，两组患者在治疗前VAS评分之间并未见显著差异（P＞0.05），两组患者关节疼痛程度均得到有效控制，但观察组疼痛评分改善情况更为显著，两组患者治疗前WOMAC评分之间并未见显著差异，治疗后，两组患者疾病程度均有所改善，但观察组患者治疗后各阶段WOMAC评分改善效果更为理想，观察组50例患者中，1例患者发生恶心情况，对照组50例患者中，有2例患者分别发生呕吐与头晕情况。结论:在膝骨关节炎疼痛患者治疗期间，与单纯用药对比，采用普瑞巴林联合硫酸软骨素治疗方案更有助于促进各项临床指标的改善，且能够在相对短的时间内缓解关节疼痛程度。

Abstract:

ABSTRACT: Objective: To investigate the effects of pregabalin combined with chondroitin sulfate on the levels of MMP-3 and TIMP-1 in patients with knee osteoarthritis pain. Methods: 100 cases of patients with knee osteoarthritis pain in our hospital were divided into two groups according to the different therapeutic schedules. 50 cases of patients were treated with chondroitin sulfate as the control group, while 50 cases of patients were treated with pregabalin combined with chondroitin sulfate as the observation group. Results: After treatment, the level of MMP-3 of patients in the observation group was significantly lower than that in the control group, the level of TIMP-1 of patients in the observation group was significantly higher than that in the control group. There was no significant difference in VAS score between the two groups before treatment (P>0.05). The joint pain of patients in both groups was effectively controlled. However, the improvement of pain score of patients in the observation group was more significant. There was no significant difference in WOMAC score between the two groups before treatment. After treatment, the joint pain degree of patients in both groups was improved. The improvement of WOMAC score of patients in the observation group was more significant in each stage. 1 case of patient occurred to nausea in the observation group. 2 cases of patients in the control group occurred to vomiting and dizziness in the control group. Conclusion: As for the treatment of knee osteoarthritis pain, compared with the simple medication, pregabalin combined with chondroitin sulfate is more conducive to the improvement of clinical indicators and can alleviate the degree of joint pain in short-time period.