Abstract:[Abstract] Objective To investigate the effectiveness and safety of ultrasound-guided stellate ganglion block in treatment of sympathetic cervical spondylosis. Methods 40 patients with sympathetic cervical spondylosis in the hospital from January 2017 to January 2018 were divided into control group and observation group by random number table, with 20 cases in each group. All the patients were treated with stellate ganglion block, control group was given blind block, while observation group was given ultrasound-guided block. After treatment for 30min, 1 week, 2 weeks, the changes of pain in the patients were evaluated by visual analogue scale (VAS); After treatment for 3 months, the curative effects were evaluated; The changes of sympathetic symptoms, spinal cord nerve function, living quality between the two groups on admission, after treatment for 1 month and 3 months were compared, and the complications of patients were recorded. Results There was no statistical difference in the efficacy between the two groups (P>0.05); After treatment for 30min, 1 week, 2 weeks, the VAS scores of two groups showed the decreased trend, and there was no statistical difference between the two groups among groups, groups and time points (P>0.05); After treatment for 1 month and 3 months, the scores of sympathetic symptoms in the two groups showed the decreased trend, the scores of spinal cord nerve function and living quality showed the increased trend, and there was no statistical difference between the two groups among groups, groups and time points (P>0.05); The incidence of postoperative complications in observation group was lower than that in control group (P<0.05). Conclusion Ultrasound-guided and blind stellate ganglion block in treatment of sympathetic cervical spondylosis are effective, they can improve sympathetic symptoms, promote spinal cord nerve function, and increase living quality. But ultrasound-guided block has better effects than blind block, it can decrease the dose of blocking drugs, achieve the lower incidence of postoperative complications and have higher treatment safety.