Abstract:Objective:To realize the influence of pre-psychology interfering on heart rate variability (HRV) and pain after surgery in patients with breast cancer. Methods:85 patients with breast cancer were divided into interfering group (43 cases) and control group (42 cases). The patients in control group were given general preparative and nursing,but those in interfering group were added psycholoy interfering.Two group were the four indexes of frequency domain analysis and Self-Rating Anxiety Scale(SAS) were recorded before surgery,and recorded grade of pain after surgery. Results:Before surgery,LF and LF/HF in interfering group were lower than control group,HF and TF in interfering group were higher than those in control group; SAS score before surgery and pain degree was lower than those in control group. Conclusion:Psychology interfering can make HRV become balance and decrease anxiety before surgery,relieve pain after surgery in patients with breast cancer.