静注氟比洛芬酯对胸科手术病人术后镇痛效应的影响

EFFECT OF FLURBIPROFEN ON POSTOPERATIVE PAIN AFTER THORACIC SURGERY

摘要:

目的:通过观察氟比洛芬酯(凯纷)对开胸手术患者的镇痛效应,探讨其在胸科术后镇痛中的可行性。方法:肺癌患者36例,随机分为3组(n=12):A组(术前静注凯纷1mg/Kg),B组(术毕静注凯纷1mg/Kg),C组(空白对照)。记录各组患者术毕清醒拔管后即刻(T1),1(T2),2(T3),4(T4),6(T5)和12小时(T6)后的VAS评分(P<0.05)。结果:术后4小时内,B组VAS评分显著高于A组(P<0.05)。术后12小时内,C组VAS评分显著高于B组和A组。接受凯纷镇痛的患者,未表现出明显的不良反应。结论:与术后给药相比,术前静注凯纷提供了更好的镇痛效果,且恶心、呕吐等副作用少见。

Abstract:

Objective: To evaluate the effect of flurbiprofen on postoperative pain in patients with thoracic surgeries, and to investigate the feasibility for flurbiprofen analgesia. Methods: Thirty-six patients suffered from lung cancer were divided into 3 groups randomly(n=12): group A (flurbiprofen 1 mg/Kg iv pre-operation),group B( flurbiprofen 1 mg/Kg iv post-operation )and group C (sham control ). VAS scales were evaluated instantly(T1),1 h(T2), 2 h(T3), 4 h(T4), 6 h (T5), and 12 h (T6) after extubation.Results: From T1 to T4, VAS was significantly higher in group B than that in group A(P<0.05). While from T1 to T6 VAS was significantly higher in group C than that in group A and B(P<0.05). At the same time, adverse effects such as nausea, vomit were seldom seen. Conclusion: Pre-operative flurbiprofen provides better analgesic effect and less adverse effects compared with post-operative medication. Preemptive analgesia with flurbiprofen is worth clinical promotion.