石菖蒲水煎剂对吗啡依赖大鼠戒断症状的治疗作用

THE EFFECTS OF ACROUSTATRINOWHSCHOTT DECOCTION ON WITHDRAWAL SYN- DROMES IN MORPHINE DEPENDENT RATS

摘要:

目的：观察石菖蒲水煎剂对吗啡依赖大鼠戒断症状的治疗作用。方法：采用连续递增皮下注射吗啡,建立吗啡依赖动物模型;给石菖蒲实验组大鼠不同剂量（2.5 g/kg、5 g/kg、7.5 g/kg）的石菖蒲水煎剂灌胃后,用纳络酮催瘾（0.5 mg/kg）,观察每组大鼠戒断反应中出现的咬牙、湿狗样抖动、扭体等六种戒断症状,评价大鼠戒断反应的强度。结果：与盐水对照组比较,石菖蒲水煎剂对吗啡依赖大鼠的戒断症状均有不同程度的抑制作用,其中以5 g/kg剂量组的作用最为突出（P〈0.01）。结论：石菖蒲水煎剂能明显抑制吗啡依赖大鼠的戒断症状。

Abstract:

Objective: To investigate the effects of acroustatrinowiischott decoction on withdrawal syndromes in morphine dependent rats.Methods: A model of morphine dependent rats was established by gradually increasing the doses of morphine subcutaneous injection in rats.In acroustatrinowiischott test groups rats took three different doses acroustatrinowiischott decoction(2.5 g/kg,5 g/kg,7.5 g/kg) with IG,then rats were injected with naloxone(0.5 mg/kg).The intensity of withdrawal syndromes was evaluated according to withdrawal syndromes such as teeth chattering,wet shakes,penile licking,weightloss,escape attempts and writhing.Results: Compared with morphine dependent control group,acroustatrinowiischott could relieve the withdrawal syndrome.The effects of 5 g/kg acroustatrinowiischott were most obvious(P<0.01).Conclusion: Acroustatrinowiischott decoction may obviously relieve morphine withdrawal syndromes in morphine dependent rats.