硬膜外注射脉络宁对脊神经根炎大鼠血清中白细胞介素-6的影响

EFFECTS OF EPIDURAL INJECTION OF MAILUONING ON SERUM IL-6 LEVEL IN THE RATS WITH RADICULITIS

摘要:

目的：通过观察脊神经根炎大鼠血清中白细胞介素-15（IL-6）的含量，探讨硬膜外腔注射脉络宁治疗椎间盘源性腰腿痛的作用机制。方法：选用Wistar雄性大鼠24只，随机分为四组：正常组（Z），假手术组（K），脉络宁组（A）和模型组（S）。A组每只硬膜外腔注入脉络宁0．6ml／kg，每四天给一次药，一共给药四次；S组给予等量生理盐水。术后第18天从右心室取血2ml，检测各组大鼠血清中IL-6的含量。结果：大鼠血清IL-6含量S组明显高于A组、Z组和K组，组间比较具有显著性差异（P〈0．01），A组与Z组相比无显著性差异（P〉0．05）。结论：硬膜外腔注射脉络宁可降低脊神经根炎大鼠血清中IL-6含量，这可能是脉络宁治疗椎间盘源性腰腿痛的机制之一。

Abstract:

Objective: To determine whether interleukin-6(IL-6) is involved in nerve root pain induced by herniated lumbar disc, and to explore the clinical mechanism of Mailuoning. Methods: 24 Wistar rats were randomly divided into four groups: normal group(Z),sham operation group(K), model group(S) and Mailuoning therapy group(A). The serum levels of IL-6 were measured 18 days after operation. Results: Serum IL-6 in Group A was very low; Groups S had the highest level of IL-6 among the four groups. IL-6 was decreased after epidural injection of Mailuoning and there was no significant difference between normal and Mailuoning groups (P>0.05). Conclusion: IL-6 may play a critical role in the development of nerve root pain. Mailuoning can decrease the serum level of IL-6.