西比灵与阿米替林防治偏头痛疗效研究

THE PREVENTATIVE AND THERAPEUTIC EFFECTS OF FLUNARIZINE COMBINED WITH AMITRIPTYLINE ON MIGRAINE

摘要:

目的：评价西比灵、阿米替林防治偏头痛的疗效。方法：采用Zung氏焦虑自评量表（SAS）及抑郁自评量表（SDS）评价偏头痛患者的焦虑和抑郁程度。将SAS或SDS评分在40分以上的偏头痛患者随机分为西比灵加阿米替林组（A组）、西比灵组（B组）和阿米替林组（C组）；比较各组间疗效的差异。结果：偏头痛患者中有抑郁者69．3％，焦虑者53．7％。治疗30天后，A组SDS及SAS评分均有所降低（P＜0．05），B组和C组则无显著改善（P＞0．05）。A组及B组治疗前后自身对照在发作次数，持续时间及对生活的影响方面评分差异均有统计学意义（P＜0．05）；C组治疗前后比较则没有统计学意义（P＞0．05）。3组间两两对比以A组防治效果最好，B组次之，C组无效。结论：西比灵加阿米替林对偏头痛有预防效果，且对其伴随的情绪障碍改善也有效。

Abstract:

Objective:To investigate the preventative and therapeutic effects of Flunarizine and /or Amitriptyline on migraine.Methods:This study used SDS and SAS to evaluate the degree of depression and anxiety in migraineurs;the migraineurs who score above 40 were employed and randomly divided into three groups:group A(Flunarizine plus Amitriptyline together),B(Flunarizine)and C(Amitriptyline),then compared the effect with each other.Results:The percentage of migraineurs with depression were and anxiety 69.8% and 53.54% respectively.After 30 days of treatment,the SAS and SDS significantly decreased in group A(P<0.05),but not in group B and C(P>0.05).There were significant improvement in the frequency and duration of headache,and influence on the life quality in group A and B(P<0.05),but not in group C(P>0.05).As a whole,the effect of Flunarizine plus Amitriptyline was most evident among all the three groups;Amitriptylinalong had no effect on relieving headache.Conclusion: Using Flunarizine and Amitriptyline together to prevent and treat migraine is an effective method;furthermore,it also helps relieve emotional disorder accompanying migraine.