氟西汀对脑卒中后中枢性疼痛的治疗作用

FLUOXETINE REDUCES CENTRAL POST-STROKE PAIN:A COMPARATIVE PILOT STUDY

摘要:

目的 :评价氟西汀对脑卒中后中枢性疼痛的治疗效果。方法 :以多虑平为对照 ,治疗过程中疼痛程度用视觉模拟评分法动态观察评价氟西汀对脑卒中后中枢性疼痛的疗效 ,并对疗效相关因素进行分析。结果 :氟西汀与多虑平治疗后VAS评分较治疗前明显降低 (P <0 .0 5 ) ,氟西汀组的药物不良反应发生率明显低于多虑平组 (P <0 .0 0 1)。结论 :氟西汀可有效治疗脑卒中后中枢性疼痛 ,疗效与多虑平相近 ,药物耐受性良好

Abstract:

Objective:To evaluate the effects of fluoxetine on central post-stroke pain (CPSP). Methods:The patients with CPSP were randomly divided into fluoxetine group and doxepin group. Pain intensity was assessed with visual analogue scale (VAS). Other factors associated with symptoms were also investigated. Results: The VAS values were decreased after treatment in both groups. The incidence of side-effect in fluoxetine-treated group was significantly lower that in doxepin-treated group. Conclusion: Fluoxetine, which has similar effectiveness with doxepin, is a good choice to relieve CPSP with less side effects.