Abstract:Objective: 47 patients with cervical disc herniation were treated by epidural minimal invasive interventional therapy. Methods: Patients were divided into two groups. Epidural catheters were inserted under the guide of X-ray scan and epidural continuous infusions were given in the first group. Both epidural continuous infusions and cervical discolysis with collagenase were given in the second group. VAS pain scores and skin touch perception scores were recorded and compared before treatment vs 14,30,60,and 90 days after treatment in both groups. Results: The cervicogenic pain was alleviated in all patients in both groups after treatment. VAS pain scores in the second group were significantly lower than those in the first group 60 and 90 days after treatment ( P <0.05). Skin touch perception scores in the second group were significantly higher than those in the first group 14,30,60 and 90 days after treatment. Conclusion: The therapeutic effects of combinated epidural continuous infusion and cervical discolysis with collagenase are much better than the epidural continuous infusions only for the treatment of cervical disc herniation.