早期镇痛疗法治疗复发性口腔溃疡的临床研究

CLINICAL STUDY ON THE EFFECTS OF PREEMPTIVE ANALGESIA ON RECURRENT APHTHOUS ULCERS

摘要:

目的 :探讨早期镇痛疗法对复发性口腔溃疡 (RAU )的疗效及临床意义。方法 :选择复发性口腔溃疡患者 6 0例 ,随机分为两组 ,每组 30例。治疗组口服万络 ,5 0mg/天 ;对照组口服替硝唑 1.0 g/天 ,观察镇痛疗法对溃疡愈合的影响。结果 :治疗、对照组用药 2天的痊愈率 :治疗组为 13.33% ,对照组为 0 % ,有显著性差异 (P <0 .0 5 ) ;治疗、对照组 2天总有效率分别为 80 %和 10 % ,有显著性差异 (P <0 .0 5 ) ;治疗 4天的痊愈率 ,镇痛治疗组为 73.33% ,明显高于对照组 33.33% ,有显著性差异 (P <0 .0 5 ) ;治疗、对照组 4天总有效率分别为 93.33%和 80 % ,差异不显著 (P >0 .0 5 )。结论 :早期镇痛疗法治疗RAU具有缓解持续顽固性疼痛、快速治愈口腔溃疡、改善进食状况的作用。

Abstract:

Objective: To study the therapeutic effects of preemptive analgesia on recurrent aphthous ulcers(RAU). Methods: 60 patients with RAU were randomly divided into the treatment group (Rofecoxib 50mg/d) and control group (Tinidazole 1,000mg/d). Results: The healing rate of the treatment group (13.33%) after 2 days was significantly higher than that of the control group (0%) ( P <0.05). There were also obvious differences of the effective rate after 2 days between the treatment group (80%) and control group (10%) ( P <0.05). There was no significant differences of total effective rate after 4 days between the treatment group(93.33%) and control group (80%) ( P >0.05), although the healing rate of treatment group (73.33%) was significantly higher than that of the control group (33.33%)( P <0.05). Conclusion: The preemptive analgesia is a good method in treatment of RAU. It could be useful for relieving intractable pain and improving food taking of patients.