罗哌卡因和布比卡因在第一产程分娩镇痛时相对效价的研究

RELATIVE POTENCIES OF BUPIVACAINE AND ROPIVACAINE FOR ANALGESIA DUR-ING THE FIRST STAGE OF LABOUR

摘要:

目的:比较罗哌卡因和布比卡因在第一产程分娩镇痛时的相对效价。方法:选择合乎条件的产妇,采用随机、双盲、序贯法设计。记录相应观察指标,监测各项生命体征。结果:罗哌卡因的最低局麻药浓度(MLAC)为0.1305(95％CI0.1198～0.142)％w/v;布比卡因的MLAC为0.1058(95％CI0.0979～0.1143)％w/v。两者之间的差别(95%CI差异0.025～0.08)具有显著性(P<0.01)。结论:罗哌卡因的相对效价为布比卡因的80％。

Abstract:

Objective: To compare the relative analgesic potencies of ropivacaine and bupivacaine during the first stage of labour. Methods: Patients were randomly asigned into the experiment in a double-blind, upand-down manner. Vital signs were recorded. Result; The MLAC of ropivacaine 0. 1305(95% CI 0. 1198 -0.1421)%w/v was significantly higher than that of bupivacaine, 0. 1058(95% CI 0.0979 -0. 1143)%w/v (P <0.01). Conclusion; The relative effect of ropivacaine is about 80% that of bupivacaine (95% CI 0.65-0.90).