阿米替林防治偏头痛的临床观察

CLINICAL OBSERVATION OF TREATMENT MIGRAINE USING AMITRYPTILINE

摘要:

目的:探索小剂量阿米替林对预防和治疗偏头痛的临床疗效、安全性和使用方法。方法:随机、单盲。阿米替林为试验组168例,西比灵为对照组126例,服药时间为3个月,疗效评价时间分别为服药后第3个月、第6个月及第9个月各一次,共3次。结果:阿米替林组的防治效果明显优于西比灵组（P<0.001）,不良反应较轻微。讨论:小剂量阿米替林防治偏头痛有肯定的疗效,而且副作用小、安全、价廉、无依赖性,并能改善睡眠,调整情绪。

Abstract:

Objective: The present study was designed to evaluate the clinical efficacy and safety of applying the method of low-dose amitryptiline for prophylaxis and treatment of migraine. Methods: Random , single blind, using amitryptiline as experiment groups of 168 , sibelium as control groups of 126. Duration of treatment lasted for three months, the evaluation of effectiveness was made 3,6,9 months after the treatment. Results: The treatment efficacy of the groups of amitryptiline was significantly better than the group of sibelium (P <0. 001 ) , and the aversive responses were. And the prophylaxis effectiveness of the group of sibelium have the same effect of placebo, no treatment function. Conclution: Low-dose amit-ryptilne have the certainty effectiveness in treatment migraine. Furthermore, less side effects, safety, cheap, no psychological dependence, simultaneity can be improved sleep and readjust emotions. Which set up a new way to treatment of migraine.