Objective: To study the possible methods to improve microvascular decompression and to enhance the therapeutic effects in the treatment of cranial nerve syndromes as trigeminal neuralgia and glos-sopharyngeal neuralgia by vascular compression. Methods: A systematic review was made for 1150 cases ( 1120 of trigeminal neuralgia and 30 of glossopharyngeal neuralgia) on whom we applied microvascular decompression. Results: The grand number of cases with satisfactory effects was 1112 with an effective rate of 96. 7% ,and no case died in this group. The complication rate dropped from 5. 6% of 5 years ago to 1. 6% of the recent 5 years. Conclusion: Various factors need to be comsidered in order to enhance the cure rate and to decrease the possible complications of microvascular decompression.