偏头痛患者血清一氧化氮测定的临床意义

CHANGES OF SERUM NITRIC OXIDE IN PATIENTS WITH MIGRAINE AND ITS CLINI CAL SIGNIFICANCE

摘要:

目的：研究偏头痛发作与患者血清一氧化氮（NO）和环磷酸鸟苷（cGMP)变化的关系及其临床意义。方法：用荧分光光度法和放射免疫法分别检测32列偏头痛发作期、25例间歇期和30例正常人血清中NO2和cGMP的含量。结果：偏头痛发作期患者血清中NO2和cGMP的含量明显高于间歇期和正常对照组（P＜0．01）。偏头痛间歇期患者血清中NO2和cGMP的含量仍高于正常对照组（P＜0．01）。结论：NO和cGMP的变化可能参与偏头痛的病理生理过程。

Abstract:

Objective: To study the relationship between migraine attack and the changes of serum nitric oxide (NO) and cGMP. Method: The amounts of serum NO 2 and cGMP were measured by fluorometric method and radioimmunoassay from 32 patients with migraine during attack,25 patients with migraine at intervals and 30 normal controls. Results: The levels of serum NO 2 and cGMP in migraine attack group were significantly higher than those in attack free interval group and control group( P <0.01). The levels of serum NO 2 and cGMP in patients at attack free interval group were still higher than those in control group ( P <0.01). Conclusion: NO and cGMP may play an important role in the pathogenesis of migraine.