太极通天液与钙离子拮抗剂防治偏头痛疗效对照研究

TAIJI TONGTIAN ORAL SOLUTION VERSUS CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF MIGRAINE

摘要:

目的对照观察太极通天液与钙离子拮抗剂防治偏头痛的临床疗效.方法将345例偏头痛患者随机分为三组太极通天液组(n=117)、钙离子拮抗剂组(n=110)和联合用药组(n=118).根据患者治疗前后头痛发作次数、头痛程度、头痛持续时间和伴随症状的变化进行疗效评定,观察期为3个月.结果(1)钙离子拮抗剂防治偏头痛的显效率为45.5%,总有效率为80.0%,与文献报告相近似;(2)太极通天液显效率为46.2%,总有效率82.9%,与钙离子拮抗剂相似;(3)联合用药组显效率63.6%,显著高于单独用药组(P＜0.01),总有效率85.6%,与单独用药组无显著差异.结论太极通天液是一种有效的偏头痛防治药物;与钙离子拮抗剂合用可提高疗效.

Abstract:

Objective:To compare the efficacies of Taiji Tongtian(TJTT) Oral Solution with Calcium channel antagonists for the treatment of migraine. Methods: 345 patients were randomly divided into three groups: Group A(n=117), treated with TJTT Oral Solution; Group B(n=110), treated with Calcium channel antagonists and Group C(n=118 ) treated with both drugs. The efficacy was assessed on the basis of the following variables: frequency of migraine attack, intensity of headache, duration of attacks and accompanying syndromes. The duration of observation was 3 months. Results: (1) The marked effective rate and total effective rate for group A were 45.5% and 80.0% respectively, which were similar with the results published in the literature.(2) The corresponding values for group B were 46.2% and 82.9%, not significantly different from that of group A. (3) The group C showed a marked effective rate of 63.6%, which was significantly higher ( P <0.01) than the corresponding values in group A and B, although the total effective rate (85.6%) remained in the same magnitude. Conclution:TJTT Oral Solution is an effective drug for the treatment of migraine. It can be used in combination with Calcium channel antagonists to increase the therapeutic efficacy.