伍用利用卡因减少异丙酚注射痛

LIDOCAINE REDUCES PAIN CAUSED BY PROPOFOL INJECTION

摘要:

目的：观察伍用不同剂量的利用卡因对异丙酚注射痛的影响。方法：２００例女性患者ＡＳＡⅠ～Ⅱ级，随机分为４组，每组５０例，采用双盲法分别静注１ｍｌ０．９％盐水、０．５％利多卡因（５ｍｇ）、１％利多卡因（１０ｍｇ）、２％利多卡因（２０ｍｇ）与１９ｍｌ１％异丙酚混合液，观察各组异丙酚注射痛的发生情况。结果：利多卡因明显减小了异丙酚静注即刻和麻醉苏醒后回忆的疼痛发生率及严重程度。利多卡因剂量与异丙酚静注疼痛的发生率及严重程度呈负相关（二者均Ｐ〈０．００１）。结论：伍用利多卡因２０ｍｇ明显减少异丙酚注射痛的发生率及严重程度。

Abstract:

Aim: To observe whether concomitant administration of lidocaine could reduce pain induced by propofol injection. Methods: In a randomized double blind trial, 200 women of ASA status 1 or 2 were allocated to one of four groups to receive 19ml of propofol mixed with either 1ml of 0.9% saline, 1ml of 0.5%(5mg) lidocaine ,1ml of 1%(10mg) lidocaine or 1ml of 2%(20mg) lidocaine. The pain of injection was recorded. Results: Lidocaine reduces the incidence and severity of pain caused by propofol injection, both during induction of anesthesia and as recalled after the surgical operation. A highly significant negative dose response relationship was observed between the dose of lidocaine and the severity of pain ( P <0.001). Conclusion: Lidocaine 20mg premixed with propofol significantly reduces the incidence and severity of pain produced by propofol injection.