Abstract:In this prospective observational study,we investigated 100 patients using epidural anesthesia for simple cholecystectomy and received intramuscular dolantin analgesia. A self reported psychological questionnaire and Wong Baker faces pain rating scale were used in order to reveal the influence of psychological factors on postoperative pain.The result of monovariate analysis suggested that neuroticism,anxiety(state anxiety and trait anxiety),cognition(patients' worrying about the operation,mental preparation,fear of postoperative pain,confidence of recovery),attention to pain and other patients' suggestion were all correlated with postoperative pain respectively. The result of multivariate analysis suggested that among the above mentioned psychological factors,state anxiety had the highest correlation with postoperative pain,the second were other patients' suggestion and patients' attention to pain. Accordingly,we put forward a proposal of applying psycho therapy in which the key point is anxiety controlling to assist postoperative analgesia.