乌拉地尔对吗啡戒断大鼠的高血压和心加速有抑制作用

THE INHIBITORY EFFECT OF URAPIDIL ON HYPERTENSION AND TACHYCARDIA IN MORPHINE WITHDRAWAL RATS

摘要:

本实验采用皮下递增注射吗啡５天后，经纳络酮催瘾建立吗啡戒断模型，观察中枢５－ＨＴ－Ａ受体激动剂乌拉地尔（ｕｒａｐｉｄｉｌ）对吗啡依赖大鼠戒断后的平均动脉压（ｍＡＢＰ）和心率（ＨＲ）的影响。实验结果表明，侧脑室微量注射乌拉地尔具有明显抑制吗啡戒断后血压升高的作用，并呈量效关系，乌拉地尔对吗啡戒断后心率加速虽也有抑制作用，但不呈量效关系，用另一种特异性５－ＨＴ１Ａ受体激动剂８－ＯＨ－ＤＰＡＴ兴奋中枢５

Abstract:

The model of morphine witharawal rats was established by gradually increasing doses of morphine (from 5mg/kg to 50mg/kg, 5 days). The effect of intracerebroventracular injection of 5 HT 1A agonist urapidil on mean arterial blood pressure (mABP) and heart rate (HR) was studied in naloxone precipitated rats . The results of present study showed that intracerebroventracular injection of urapidil may inhibit the hypertention in morphine withdrawal rats in a dose dependent manner. Urapidil also inhibited the tachycardia in morphine withdrawal rats, but not in a dose dependent manner. Similar results were obtained by intracerebroventracular injection of 5 HT 1A agonist 8 OH DPAT.