癌症疼痛与机体免疫水平关系的临床研究

CLINICAL STUDY OF THE RELATIONSHIP BETWEEN THE CANCER PAIN AND THE IMMUNE FUNCTION

摘要:

目的：探讨癌症疼痛与机体免疫水平的关系。方法：对７０ 例中晚期癌症病人进行细胞免疫及体液免疫检测。其中４０ 例癌痛患者，在疼痛期及疼痛缓解期分别检测细胞免疫及体液免疫；对止痛药治 疗无效的癌痛患者，加用中药免疫治疗，观察机体免疫功能对疼痛的影响。结果（１） 癌痛患者与无痛患者比较、癌痛期间与癌痛缓解期间进行比较，细胞免疫（ Ｔ， Ｃ 亚群及 Ｉ Ｌ２） 及体液免疫（ Ｉｇ Ａ， Ｃ３ ， Ｃ４） 水平均显著降低（ Ｐ ＜ ０ ．０５ 或 Ｐ ＜ ０ ．０１）） ；（２） 止痛药治疗无效加用中药免疫治疗后，８ 例中６例癌痛缓解，２ 例完全缓解。结论：癌痛与机体免疫功能可能有一定关系。镇痛治疗可提高免疫功能，而加强免疫功能有助于控制癌症痛。

Abstract:

Objective:To observe the relationship between the cancer pain and the immune function of cancer patients. Methods: 70 patients with advanced carcinoma were tested for their immune function. 40 patients were tested for cytoimmunity and humoral immunity during pain and pain remission. Patients who did not respond to analgesics were given Chinese herb for immunotherapy. Their effects on immune function was observed.Results: There was a significant reduction in cytoimmunity (T cell subset, IL 2) and humoral immunity (IgA,C3,C4) in patients with cancer pain. Eight patients who did not respond to analgesics were given Chinese herb for immunotherapy. Six out of 8 showed canar pain remission. Conclusion: An interrelationship seems to exist between canar pain and the immune function. Successful treatment of cancer pain increases immune function, and succesful induction of immune function produces a reduction of cancer pain.