多次联合注射可乐定与氯胺酮对单发性佐剂性关节炎的治疗作用

REPEATED INJECTION OF KETAMINE COMBINED WITH CLONIDINE FOR THE TREATMENT OF ADJUVANT MONOARTHRITIS IN RATS

摘要:

目的：观察多次联合注射氯胺酮及可乐定对关节炎的治疗作用。方法：用半剂量法设计实验，观察皮下联合注射氯胺酮（剂量固定）及可乐定（剂量变动）对单发性佐剂性关节炎的治疗作用。给药方式为每天皮下注射一次，每周５次，共治疗４周。疼痛评分采用背屈踝关节测痛试验，一周评分一次，动物的一般状况以体重增长速率为指标，炎症程度用踝周长表示。结果：（１）皮下联合注射氯胺酮及可乐定产生的镇痛效应显著大于单独注射氯胺酮（１

Abstract:

Objective: To observe the effect of repeated combined injection of ketamine and clonidine for the treatment of rat adjuvant monoarthritis. Method: Rats with ankle monoarthritis were given subcutaneous(s.c.) injection of ketamine (fixed dose) and clonidine (varing doses), once a day, 5 times per week for a total of 4 weeks. Scores of pain were tested by dorsal flexion of ankle joint. Percent increase of body weight was taken as an index of general condition, and the swelling degree was expressed by the change of circumference of ankle. Results: (1) The combined injection of ketamine and clonidine in a ratio of 5mg/kg:20g/kg or 5mg/kg:40g/kg produced significantly more potent analgesia than that of injection of ketamine(10mg/kg) or clonidine(40 or 80g/kg) alone. (2) The sweelling degree of the inflamed ankle showed no significant difference between the combined injection group and the single injection group. (3) No significant changes were observed in body weight between the groups. Conclusions: Repeated injections of optimal combination of ketamine and clonidine produced synergistic analgesia without significant aversive side effects.