星状神经节阻滞对细胞免疫功能的影响：兼论维生素B的作用

INFLUENCE OF STELLATE GANGLION BLOCK ON CELLULLAR IMMUNITY

摘要:

目的：观察利多卡因和维生素Ｂ类星状神经节阻滞对红细胞及ＮＫ细胞免疫功能的影响。方法：选择交感型和／或椎动脉型颈椎病病人２４例，随机分为４组，用不同药物行单侧星状神经节阻滞，每日一次，两侧交替，共７天。并于阻滞前，阻滞后３０分钟及７天后取外周血测定红细胞－Ｃ３ｂ受体花环率，红细胞－免疫合物花环率和ＮＫ细胞活性，结果：ＬＶＢ（利多卡因＋ＶＢ６＋ＶＢ１２）组和ＬＮＳ（利多卡因＋ＮＳ）组可显著提高红细胞了

Abstract:

Aim: This work was carried out to study the influence of stellate ganglion block(SGB) with different drugs on cellular immunity. Methods: 24 adult patients with sympathetic and/or vertebral arterial type spondylosis were selected. They were randomly divided into 4 groups and received SGB once a day for 7 days by the route of paratrachea. The rosette rate of red blood cell C 3b receptor (RBC C 3b R) and red blood cell immune complex (RBC IC) as well as the activity of NK cell were measured respectively before and after SGB. Results: group LVB (lidocaine vitamin B) and LNS (lidocaine normal saline) significantly enhance the cellular immunity, Group LVB inhibit the NK cell activity simultaneously. Group VB and NS have no obvious effects on the cellullar immunity. Conclusion: Local anesthetic (lidocaine) plays a critical role in the effect of SGB on the cellular immunity. The vitamine B 6 and B 12 seem not necessary in this regard. The depressive effect on NK cell activity should be paid attention to during the clinical use.