中脑导水管周围灰质内催产素对痛阈和电针镇痛效应的影响

THE EFFECT OF OXYTOCIN IN PERIAQUEDUCTAL GRAY ON PAIN THRESHOLD AND ELECTROACUPUNCTURE ANALGESIA

摘要:

本工作以钾离子透入法引起大鼠甩尾反应的电流强度（ｍＡ）为痛反应指标，观察了中脑导水管周围灰质（ＰＡＧ）腹外侧区注射催产素（ＯＴ）和抗催产素血清（ＡＯＴＳ）对大鼠痛阈和电针镇痛效应的影响。结果表明，ＰＡＧ注射ＯＴ能增加大鼠痛阈和电针镇痛效应；注射ＡＯＴＳ以中和内源性的ＯＴ后，对大鼠痛阈虽克明显影响，但能显著降低电针期的停针后的电针镇痛效应。提示ＰＡＧ内生理水平的ＯＴ在电针镇痛中发挥一定作用。

Abstract:

The effect of periaqueductal gray (PAG) injection of oxytocin (OT) and anti oxytocin serum (AOTS) on the pain threshold and electroacupunctjure (EA) analgesia in rats were investigated in this study. The potassium iontophoresis induced tail flick was used to measure the pain threshold. PAG injection of OT not only raise the pain threshold, but also enhanced the EA analgesia. Injection of AOTS could weaken the analgesic effect of EA significantly, but it did not change the pain threshold. These results suggest that endogenous oxytocin in the PAG may play a role in the electroacupuncture analgesia.