中枢5—HT1,5—HT2及5—HT3受体对吗啡戒断反应的影响

THE EFFECT OF CENTRAL 5-HT_1, 5-HT_2 and 5-HT_3 RECEPTOR ON MORPHINE WITHDRAWAL SYNDROMES IN RATS

摘要:

本工作给吗啡成瘾大鼠侧室注射５－ＨＴ１、５－ＨＴ１及５－ＨＴ３受体激动剂１－（３－ｃｈｌｏｒｏｐｈｅｎｙｌ）ｐｉｐｅｒａｚｉｎｅ（简写ｍ－ｃｐｐ），α－ＣＨ３－５ＴＨ，２－ＣＨ３－５ＨＴ以及５－ＨＴ１受体拮抗剂Ｍｅｔｈｉｏｔｈｅｐｉｎ ｍｅｓｙｌａｔｅ和５－ＨＴ２受体拮抗剂Ｒｅｔａｎｓｅｒｉｎｅ，观察对吗啡戒断反应的影响。实验结果表明，激动５－ＨＴ１受体和５－ＨＴ２受体可加重纳洛酮诱发的躯体戒断反

Abstract:

The results of the present study showed that intracerebroventricular injection of 5-HT1 and 5-HT2 agonist 1-(3-chlorophenyl) piprazine and Q-CH3-5-HT in rat exagerated the morphine withdrawal syndromes, but there is no effect of 5-HT3 agonist (2-CH3-5-HT) on morphine withdrawal syndromes. It was also found that intracerebroventricular injection of methiothepin mesylate and retanserine, the blockers of 5-HT1 and 5-HT2 receptors, could relieve the morphine withdrawal syndrome dose-dependently. The suppressive effect of retanserine was much stronger than that of metheothepin. This finding may have implication in selecting new therapeutic medicine for morphine withdrawatl syndnomes.