Abstract:We have treated 15 patients with cancer pain by X-knife, using single isocenter and 5mm collimators,destorying the VPL or VPM aam presicribed dose was 120 Gy and the target was ended by 100% isodose line. The effective rate is 73.3%. During the 4-11 months follow-up, there has no relate of the cancer pain and any other complications related with X-knife treatment. We think that the stereotaxic radioneurgery(SRNS) may be one of the methods to cure the cancer pain.