Abstract:Lyme disease which was first described in USA in 1975 and was reported in Chinain 1980s is a tick-borne infectious disease caused by Borrelia burgdorferi.Multisystem maybe involved in Lyme disease.This paped roports 2 cases with episodic hesdathe as main mani festation of Lyme disease,which has not been documented.The characteristics of theheadache were described and the therapy for Lyme disease was discussed. The authors pointout that timely and accurate diagnosis is very important for the treatment of the headache ofLyme disease.