硬膜外注入吗啡与吗啡复合药对癌痛镇痛疗效的观察

EFFECT OF CANCER PAIN RELIEF BY EPIDURAL ADMINISTRATION OF SINGLE OR COMBINED MORPHINE

摘要:

４０例晚期重度癌痛病人应用吗啡与吗啡复合药行硬膜外注药镇痛。使用药物分为三种，第三种为吗啡，第二种为吗啡＋氯胺酮，第三种为吗啡＋氟哌啶。从平均起效时间比较，两一啡复合组（８．２，８．２ｍｉｎ）比单纯吗啡组（９．５ｍｉｎ）为优（Ｐ〈０．０５）差异有统计学意义。从镇痛时间比较，两吗啡复合组（６．７３，６．９０ｈ）较单纯吗啡组作用时程（５．２３ｈ），显著延长（Ｐ〈０．００１），显示两吗啡复合组疗效更优。

Abstract:

Epidural injection of single or combined Morphine was used for analgesia on 40patients suffering from sever late cancer pain.Patients were divided into three groups admi nistered with:1,morphine only;2,morphine and ketamine;3,morphine and droperidol.Theresults showed that both of the combined morphine groups were better then sigle morphinegroup in terms of the latency of analgesic effect(9.5min in Group 1 versus 8.2 and 8.4min in Group 2 and 3,P<0.05)and the duration of analgesia(5.23h in Group 1 versus6.73 and 6.90 min in Group 2 and 3,P<0.01).The rssults indicate that the analgesic e ffect of the combined morphine groups is better than that of morphine only group.